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Fragmentation of Singly Charged Peptide Ions by Photodissociation at λ =157 nm
Author(s) -
Thompson Matthew S.,
Cui Weidong,
Reilly James P.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460788
Subject(s) - fragmentation (computing) , photodissociation , ion , dissociation (chemistry) , chemistry , photochemistry , protonation , excited state , mass spectrum , electron ionization , collision induced dissociation , electron capture dissociation , bond cleavage , electron , mass spectrometry , tandem mass spectrometry , atomic physics , physics , ionization , organic chemistry , catalysis , fourier transform ion cyclotron resonance , quantum mechanics , chromatography , computer science , operating system
A study in contrasts : Mass spectra of singly protonated peptide ions excited with 157‐nm light show unorthodox fragmentation patterns in comparison to those obtained by collision‐induced dissociation (CID). Observations are consistent with an initial photochemical cleavage of α‐CCO bonds in the peptide backbone by a Norrish Type I reaction to create radical precursor ions followed by one of three elimination processes that form ion fragments with even numbers of electrons.