Premium
A Highly Stereoselective Addition of the Anion Derived from α‐Diazoacetamide to Aromatic N ‐Tosylimines
Author(s) -
Zhao Yonghua,
Ma Zhihua,
Zhang Xiaomei,
Zou Yaping,
Jin Xianglin,
Wang Jianbo
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460730
Subject(s) - stereoselectivity , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
In the presence of an Evans oxazolidinone as the chiral auxiliary, the anion derived from α‐diazoacetamide adds to aromatic N ‐tosylimines with high stereoselectivity (see scheme). The addition products can be used in a concise and stereoselective synthesis of syn ‐ and anti ‐α‐hydroxy‐β‐amino acid derivatives.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom