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One‐Pot Optical Resolution of Oligopeptide Helices through Artificial Peptide Bundling
Author(s) -
Guo YanMing,
Oike Hideaki,
Saeki Naoko,
Aida Takuzo
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460703
Subject(s) - oligopeptide , chirality (physics) , chemistry , peptide , enantiomer , porphyrin , stereochemistry , biochemistry , physics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
T he helical sense of the peptidic parts of a cyclodimeric zinc porphyrin host with helical oligopeptide units ( 1 ) determines whether a right‐ or left‐handed oligopeptide guest ( 2 ) is selectively bound (see picture). In contrast, enantiomers of nonhelical peptidic guests containing a point chirality are hardly discriminated.