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Direct Catalytic Enantioselective α‐Aminomethylation of Ketones
Author(s) -
Ibrahem Ismail,
Casas Jesús,
Córdova Armando
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460678
Subject(s) - enantioselective synthesis , mannich reaction , yield (engineering) , chemistry , catalysis , organic chemistry , combinatorial chemistry , ketone , organocatalysis , component (thermodynamics) , proline , amino acid , materials science , metallurgy , biochemistry , physics , thermodynamics
A proline‐catalyzed Mannich reaction produces α‐aminomethylated ketones in high yield and with excellent ee values (see scheme). The Mannich bases resulting from this highly practical one‐pot three‐component asymmetric reaction are of particular interest, for example, as synthetic building blocks and precursors of pharmaceutically valuable 1,3‐amino alcohols.