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Transition‐Metal‐Catalyzed Benzylation of Arenes and Heteroarenes
Author(s) -
Mertins Kristin,
Iovel Irina,
Kischel Jette,
Zapf Alexander,
Beller Matthias
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460666
Subject(s) - catalysis , chemistry , friedel–crafts reaction , transition metal , organic chemistry , metal , combinatorial chemistry
Friedel–Crafts‐type benzylation of various aromatic and heteroaromatic compounds with benzylic acetates, alcohols, and carbonates was promoted under mild reaction conditions by a series of Rh, Ir, Pd, and Pt catalysts (see scheme; R 1 =H, Me; R 2 =H, Cl, MeO; R 3 =H, Ac, CO 2 Me). The desired products were obtained in high yields and with high selectivities.