Premium
Elisabethin A: A Marine Diterpenoid Yet To Surrender to Total Synthesis
Author(s) -
Zai Giuseppe,
Franzini Maurizio
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460570
Subject(s) - total synthesis , surrender , whip (tree) , natural product , natural (archaeology) , geography , chemistry , stereochemistry , biology , paleontology , botany , archaeology
Mysterious and elusive , elisabethin A ( 1 , pictured with the West Indian sea whip Pseudopterogorgia elisabethae from which it was isolated), has not yet succumbed to total synthesis—or has it? Two recent attempts at the synthesis of this challenging target are examined, but questions still remain as to the absolute configuration of the natural product and the synthetic material.