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Reversible Cross‐Linking of Hyperbranched Polymers: A Strategy for the Combinatorial Decoration of Multivalent Scaffolds
Author(s) -
Barth Michael,
Fischer Rainer,
Brock Roland,
Rademann Jörg
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460559
Subject(s) - polymer , polymer science , dendrimer , materials science , polymer chemistry , nanotechnology , chemistry , chemical engineering , combinatorial chemistry , composite material , engineering
All decked out : Peptide‐decorated dendritic polymers were synthesized on macroscopic polymer resins and then released by cleaving the reversible cross‐linkers (see scheme). The released multivalent structures entered cells efficiently at low concentrations by endocytosis.