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Targeting RNAs with Tobramycin Analogues
Author(s) -
Liang FuSen,
Wang ShengKai,
Nakatani Takuji,
Wong ChiHuey
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460558
Subject(s) - tobramycin , ring (chemistry) , rna , chemistry , selectivity , drug , combinatorial chemistry , stereochemistry , computational biology , biology , antibiotics , pharmacology , biochemistry , gene , organic chemistry , gentamicin , catalysis
A library of 4,6‐linked analogues of the drug tobramycin with various mono‐ or diaminosugars attached to the 6‐position of the two‐ring core has been prepared (see scheme; Bn=benzyl, Tol= p ‐tolyl). The compounds were screened against different disease‐related RNAs, and several of the synthetic analogues showed a high affinity and selectivity toward certain RNA sequences.