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α,α‐Difluoro‐ H ‐phosphinates: Useful Intermediates for a Variety of Phosphate Isosteres
Author(s) -
Gautier Arnaud,
Garipova Goulnara,
Salcedo Carmen,
Balieu Sébastien,
Piettre Serge R.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460519
Subject(s) - chemistry , phosphate , sodium salt , salt (chemistry) , phosphorus , sodium , medicinal chemistry , organic chemistry , combinatorial chemistry , inorganic chemistry
Addition of the radical generated from the sodium salt of hypophosphorous acid to difluoroalkenes results in the formation of α,α‐difluoro‐ H ‐phosphinates. These intermediates can be transformed into different phosphorus‐centered isosteres, such as difluorophosphonates, difluorophosphonothioates, and difluorophosphinates (see scheme).