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Unveiling Reliable Catalysts for the Asymmetric Nitroaldol (Henry) Reaction
Author(s) -
Palomo Claudio,
Oiarbide Mikel,
Mielgo Antonia
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460506
Subject(s) - nitroaldol reaction , catalysis , selectivity , lewis acids and bases , enantioselective synthesis , value (mathematics) , chemistry , combinatorial chemistry , organic chemistry , computer science , machine learning
Conceptually different chiral catalysts ranging from polymetallic complexes to Lewis acids and organocatalysts have emerged for solving the long‐standing problem of stereocontrol in the Henry reaction, a fundamental CC bond‐forming process (see scheme). New catalyst systems with improved selectivity have increased the synthetic value of this reaction considerably.