Premium
Cross‐Coupling of Alkyl Halides with Aryl Grignard Reagents Catalyzed by a Low‐Valent Iron Complex
Author(s) -
Martin Rubén,
Fürstner Alois
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460504
Subject(s) - aryl , alkyl , halide , reagent , catalysis , magnesium , chemistry , reactivity (psychology) , coupling reaction , grignard reagent , coupling (piping) , medicinal chemistry , organic chemistry , materials science , metallurgy , medicine , alternative medicine , pathology
A striking reversal of the usual reactivity pattern of aryl Grignard reagents is observed for reactions in the presence of catalytic amounts of the “bare” ferrate complex [Li(tmeda)] 2 [Fe(C 2 H 4 ) 4 ] ( 1 ). Highly reduced iron–magnesium clusters may play a decisive role in the exceptionally facile and chemoselective cross‐coupling reaction with alkyl halides (see scheme).