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Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery
Author(s) -
Pantarotto Davide,
Singh Ravi,
McCarthy David,
Erhardt Mathieu,
Briand JeanPaul,
Prato Maurizio,
Kostarelos Kostas,
Bianco Alberto
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460437
Subject(s) - carbon nanotube , gene delivery , dna , nanotechnology , plasmid , genetic enhancement , gene , materials science , nanotube , biophysics , chemistry , biology , biochemistry
Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water‐soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.