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Zirconium Triflate Catalyzed Direct Coupling Reaction of Lactams with Heterocyclic Arenes under Atmospheric Oxygen
Author(s) -
Tsuchimoto Teruhisa,
Ozawa Yoshitaka,
Negoro Ryoju,
Shirakawa Eiji,
Kawakami Yusuke
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460429
Subject(s) - catalysis , trifluoromethanesulfonate , oxygen atom , zirconium , chemistry , coupling (piping) , oxygen , nitrogen atom , nitrogen , coupling reaction , atom (system on chip) , atmosphere (unit) , carbon fibers , photochemistry , medicinal chemistry , polymer chemistry , inorganic chemistry , organic chemistry , ring (chemistry) , materials science , molecule , physics , composite number , computer science , metallurgy , composite material , thermodynamics , embedded system
Exclusive coupling : High turnover numbers were attained in the dehydrogenative coupling reaction between C(sp 2 ) and C(sp 3 ) atoms. A zirconium catalyst mediates the coupling reactions of heterocyclic arenes and lactams exclusively at the carbon atom adjacent to the nitrogen atom of the latter under an oxygen atmosphere (see scheme).