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Allosteric and Electrostatic Reprogramming of a Ditopic Ligand
Author(s) -
Baylies Christian J.,
Harding Lindsay P.,
Jeffery John C.,
RiisJohannessen T.,
Rice Craig R.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460424
Subject(s) - ligand (biochemistry) , chemistry , allosteric regulation , thiazole , stereochemistry , ether , biochemistry , enzyme , receptor , organic chemistry
A potentially tetradentate pyridyl–thiazole ligand chain and an additional “external” crown ether binding site connect the two halves of a new ditopic ligand. The pyridyl‐thiazole binding sites can be changed or “reprogrammed” by the addition of Ba 2+ : In the presence of Hg 2+ and Na + the ligand L 1 forms a dinuclear double helicate ([Hg 2 (L 1 ) 2 Na 2 ] 6+ ), whereas in the presence of Hg 2+ and Ba 2+ a mononuclear species is formed ([Hg(L 1 )Ba] 4+ ).
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