The Isolation and Crystal Structure of a Cyclic Selenenate Ester Derived from Bis(2,6‐diformyl‐4‐ tert ‐butylphenyl)diselenide and its Glutathione Peroxidase‐Like Activity | Zendy

Zade Sanjio S. | Zendy; Singh Harkesh B. | Zendy; Butcher Ray J. | Zendy

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The Isolation and Crystal Structure of a Cyclic Selenenate Ester Derived from Bis(2,6‐diformyl‐4‐ tert ‐butylphenyl)diselenide and its Glutathione Peroxidase‐Like Activity

Author(s) -

Zade Sanjio S.,

Singh Harkesh B.,

Butcher Ray J.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200460380

Subject(s) - diselenide , intramolecular force , chemistry , peroxidase , stereochemistry , catalysis , enzyme , medicinal chemistry , organic chemistry , selenium

Enzyme mimicry : Halogenation of diselenide 1 affords the cyclic selenenate ester 2 (see scheme) through a highly unstable selenenic acid intermediate. Compound 2 exhibits a strong intramolecular nonbonding Se⋅⋅⋅O interaction. Both 1 and 2 show excellent glutathione peroxidase‐like catalytic activity.

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