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The Isolation and Crystal Structure of a Cyclic Selenenate Ester Derived from Bis(2,6‐diformyl‐4‐ tert ‐butylphenyl)diselenide and its Glutathione Peroxidase‐Like Activity
Author(s) -
Zade Sanjio S.,
Singh Harkesh B.,
Butcher Ray J.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460380
Subject(s) - diselenide , intramolecular force , chemistry , peroxidase , stereochemistry , catalysis , enzyme , medicinal chemistry , organic chemistry , selenium
Enzyme mimicry : Halogenation of diselenide 1 affords the cyclic selenenate ester 2 (see scheme) through a highly unstable selenenic acid intermediate. Compound 2 exhibits a strong intramolecular nonbonding Se⋅⋅⋅O interaction. Both 1 and 2 show excellent glutathione peroxidase‐like catalytic activity.