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Generation of Dynamic Constitutional Diversity and Driven Evolution in Helical Molecular Strands under Lewis Acid Catalyzed Component Exchange
Author(s) -
Giuseppone Nicolas,
Schmitt JeanLouis,
Lehn JeanMarie
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460343
Subject(s) - catalysis , component (thermodynamics) , dissociation (chemistry) , yield (engineering) , chemistry , recombination , lewis acids and bases , combinatorial chemistry , crystallography , stereochemistry , materials science , physics , organic chemistry , biochemistry , metallurgy , thermodynamics , gene
A stir in the library : The efficient Sc(OTf) 3 ‐catalyzed transimination of helical oligohydrazone strands has been utilized to yield a highly diverse constitutional dynamic library through assembly, dissociation, and exchange of components. This library can subsequently undergo driven evolution in the presence of Zn II ions to express preferentially [2×2] gridlike arrays by component recombination.