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Enantioselective Allylation of Aromatic Amines after In Situ Generation of an Activated Cyclometalated Iridium Catalyst
Author(s) -
Shu Chutian,
Leitner Andreas,
Hartwig John F.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460276
Subject(s) - enantioselective synthesis , iridium , phosphoramidite , catalysis , chemistry , in situ , amine gas treating , reagent , ligand (biochemistry) , combinatorial chemistry , organic chemistry , dna , biochemistry , receptor , oligonucleotide
Highly regio‐ and enantioselective allylation of aromatic amines is observed when a cyclometalated Ir–phosphoramidite complex is generated in situ (see scheme). The active catalyst can be formed from [{Ir(cod)Cl} 2 ] and ligand L with a volatile alkylamine prior to addition of the reagents or upon use of a tertiary amine additive.