Enantioselective Allylation of Aromatic Amines after In Situ Generation of an Activated Cyclometalated Iridium Catalyst | Zendy

Shu Chutian | Zendy; Leitner Andreas | Zendy; Hartwig John F. | Zendy

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Enantioselective Allylation of Aromatic Amines after In Situ Generation of an Activated Cyclometalated Iridium Catalyst

Author(s) -

Shu Chutian,

Leitner Andreas,

Hartwig John F.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200460276

Subject(s) - enantioselective synthesis , iridium , phosphoramidite , catalysis , chemistry , in situ , amine gas treating , reagent , ligand (biochemistry) , combinatorial chemistry , organic chemistry , dna , biochemistry , receptor , oligonucleotide

Highly regio‐ and enantioselective allylation of aromatic amines is observed when a cyclometalated Ir–phosphoramidite complex is generated in situ (see scheme). The active catalyst can be formed from [{Ir(cod)Cl} 2 ] and ligand L with a volatile alkylamine prior to addition of the reagents or upon use of a tertiary amine additive.

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