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Simple Synthesis of Nodulation‐Factor Analogues Exhibiting High Affinity towards a Specific Binding Protein
Author(s) -
Grenouillat Nathalie,
Vauzeilles Boris,
Bono JeanJacques,
Samain Eric,
Beau JeanMarie
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460275
Subject(s) - sinorhizobium meliloti , nod , nod factor , biochemistry , chemistry , glycolipid , combinatorial chemistry , biology , stereochemistry , symbiosis , bacteria , rhizobia , gene , genetics , mutant
A “Nod” in the right direction : Aromatic analogues of the lipooligosaccharidic nodulation (Nod) factors involved in the symbiosis of Sinorhizobium meliloti and legumes are easily assembled from very simple precursors by combining biotechnological and chemical procedures. Some of these analogues (see structure) bind tightly to a specific binding protein and form a new class of glycolipid mimics.