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Directed Evolution as a Method To Create Enantioselective Cyclohexanone Monooxygenases for Catalysis in Baeyer–Villiger Reactions
Author(s) -
Reetz Manfred T.,
Brunner Birgit,
Schneider Toni,
Schulz Frank,
Clouthier Christopher M.,
Kayser Margaret M.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460272
Subject(s) - desymmetrization , cyclohexanone , enantioselective synthesis , monooxygenase , catalysis , chemistry , organic chemistry , stereochemistry , combinatorial chemistry , enzyme , cytochrome p450
The direction and degree of enantioselectivity in the cyclohexanone monooxygenase catalyzed air‐mediated Baeyer–Villiger reactions, such as the desymmetrization of 1 , can be controlled by directed evolution.