Nickel‐Catalyzed Cross‐Coupling Reaction of Alkyl Halides with Organozinc and Grignard Reagents with 1,3,8,10‐Tetraenes as Additives | Zendy

Terao Jun | Zendy; Todo Hirohisa | Zendy; Watanabe Hideyuki | Zendy; Ikumi Aki | Zendy; Kambe Nobuaki | Zendy

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Nickel‐Catalyzed Cross‐Coupling Reaction of Alkyl Halides with Organozinc and Grignard Reagents with 1,3,8,10‐Tetraenes as Additives

Author(s) -

Terao Jun,

Todo Hirohisa,

Watanabe Hideyuki,

Ikumi Aki,

Kambe Nobuaki

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200460246

Subject(s) - halide , reagent , alkyl , chemistry , catalysis , nickel , fluoride , coupling (piping) , grignard reaction , combinatorial chemistry , grignard reagent , medicinal chemistry , organic chemistry , inorganic chemistry , materials science , metallurgy

Essential additives : The addition of bis(1,3‐butadienyl) compounds (tetraenes) was essential in the efficient Ni‐catalyzed cross‐coupling of organozinc reagents with alkyl bromides and a tosylate (see scheme, X=C(CO 2 Me) 2 or NCH 2 Ph). The efficiency of the Ni‐catalyzed cross‐coupling of an alkyl fluoride with a Grignard reagent was also improved by using these tetraenes.

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