Efficient Whole‐Cell Biotransformation in a Biphasic Ionic Liquid/Water System | Zendy

Pfruender Holger | Zendy; Amidjojo Maya | Zendy; Kragl Udo | Zendy; WeusterBotz Dirk | Zendy

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Efficient Whole‐Cell Biotransformation in a Biphasic Ionic Liquid/Water System

Author(s) -

Pfruender Holger,

Amidjojo Maya,

Kragl Udo,

WeusterBotz Dirk

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200460241

Subject(s) - biotransformation , ionic liquid , biocatalysis , chemistry , cofactor , substrate (aquarium) , biocompatible material , ethanol , combinatorial chemistry , product inhibition , chromatography , chemical engineering , biochemistry , catalysis , enzyme , non competitive inhibition , biomedical engineering , biology , medicine , engineering , ecology

Biocompatible ionic liquids act as a substrate reservoir and an in situ extracting agent in biotransformations with whole cells (see scheme). In the reduction of 4‐chloroacetophenone to ( R )‐1‐(4‐chlorophenyl)ethanol, high product concentration (82 g L −1 ) and purity (99.6 % ee ) were achieved without the addition of cofactors and without damaging the biocatalyst.

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