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Highly Enantioselective Iron‐Catalyzed Sulfide Oxidation with Aqueous Hydrogen Peroxide under Simple Reaction Conditions
Author(s) -
Legros Julien,
Bolm Carsten
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460236
Subject(s) - hydrogen peroxide , catalysis , chemistry , enantioselective synthesis , sulfide , benzoic acid , aqueous solution , derivative (finance) , combinatorial chemistry , organic chemistry , inorganic chemistry , financial economics , economics
An attractive alternative to the currently existing methods for the metal‐catalyzed oxidation of sulfides to sulfoxides is asymmetric iron‐catalyzed oxidation with hydrogen peroxide as the terminal oxidant (see scheme). In the presence of a benzoic acid derivative, this simple process provides sulfoxides with up to 96 % ee in moderate to good yields (up to 78 %).