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Genetic Control by a Natural Metabolite‐Responsive Ribozyme
Author(s) -
Micura Ronald
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460233
Subject(s) - ribozyme , riboswitch , gene , computational biology , biology , rna , gene expression , genetics , regulation of gene expression , ligase ribozyme , non coding rna
Another striking example for the functional diversity of RNA is represented by the recently discovered riboswitch ribozyme in the leader sequence of bacterial mRNAs. A simple mechanism is responsible for controlling expression of the corresponding gene (see scheme) and demonstrates that gene regulation is no longer a domain necessarily assisted by proteins.