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A β‐Carboline‐1‐one Mimic of the Anticancer Amaryllidaceae Constituent Pancratistatin: Synthesis and Biological Evaluation
Author(s) -
Rinner Uwe,
Hudlicky Tomas,
Gordon Heather,
Pettit George R.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460218
Subject(s) - dihydroxylation , enantioselective synthesis , indole test , derivative (finance) , combinatorial chemistry , chemistry , stereochemistry , computational biology , biochemistry , biology , business , catalysis , finance
New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1 .