A β‐Carboline‐1‐one Mimic of the Anticancer  Amaryllidaceae  Constituent Pancratistatin: Synthesis and Biological Evaluation | Zendy

Rinner Uwe | Zendy; Hudlicky Tomas | Zendy; Gordon Heather | Zendy; Pettit George R. | Zendy

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A β‐Carboline‐1‐one Mimic of the Anticancer Amaryllidaceae Constituent Pancratistatin: Synthesis and Biological Evaluation

Author(s) -

Rinner Uwe,

Hudlicky Tomas,

Gordon Heather,

Pettit George R.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200460218

Subject(s) - dihydroxylation , enantioselective synthesis , indole test , derivative (finance) , combinatorial chemistry , chemistry , stereochemistry , computational biology , biochemistry , biology , business , catalysis , finance

New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1 .

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