Premium
Total Synthesis of Lepadins B, D, E, and H; Determination of the Configuration of the Latter Three Alkaloids
Author(s) -
Pu Xiaotao,
Ma Dawei
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460128
Subject(s) - total synthesis , bicyclic molecule , stereochemistry , chemistry , combinatorics , mathematics
A common bicyclic intermediate was used in an efficient strategy towards lepadins B, D, E, and H shown. These alkaloids are members of a family of natural products with diverse biological activity. The described total syntheses of lepadins D, E, and H enabled the full elucidation of their configuration.