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Ozone in Arteriosclerotic Plaques: Searching for the “Smoking Gun”
Author(s) -
Sies Helmut
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460118
Subject(s) - ozonolysis , ozone , endogeny , chemistry , environmental chemistry , biochemistry , organic chemistry
Ozone as an endogenous compound? The discovery of 5,6‐secosterol, a characteristic product of the in vitro ozonolysis of cholesterol, in atherosclerotic tissue (see picture) suggests that ozone is formed by biochemical processes. This and other typical products of oxidation may serve as indicators (“biomarkers”) of endogenous ozone.