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Biomimetic Oxidation of Chromium( III ): Does the Antidiabetic Activity of Chromium( III ) Involve Carcinogenic Chromium( VI )?
Author(s) -
Mulyani Irma,
Levina Aviva,
Lay Peter A.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460113
Subject(s) - chromium , chemistry , biochemistry , enzyme , phosphatase , insulin receptor , protein tyrosine phosphatase , insulin , biology , insulin resistance , microbiology and biotechnology , organic chemistry
The insulin‐enhancing activities of some Cr III complexes, such as [Cr 3 O(OCOEt) 6 (OH 2 ) 3 ] + ( 1 ), previously attributed to specific interactions of Cr III ions with cellular insulin receptors, are more likely to be caused by the formation of [CrO 4 ] 2− ( 2 ). Oxidation of 1 to 2 by biologically relevant oxidants, including enzymes (see scheme), and inhibition of an isolated protein tyrosine phosphatase by a Cr VI complex are reported.