Biomimetic Oxidation of Chromium( III ): Does the Antidiabetic Activity of Chromium( III ) Involve Carcinogenic Chromium( VI )? | Zendy

Mulyani Irma | Zendy; Levina Aviva | Zendy; Lay Peter A. | Zendy

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Biomimetic Oxidation of Chromium( III ): Does the Antidiabetic Activity of Chromium( III ) Involve Carcinogenic Chromium( VI )?

Author(s) -

Mulyani Irma,

Levina Aviva,

Lay Peter A.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200460113

Subject(s) - chromium , chemistry , biochemistry , enzyme , phosphatase , insulin receptor , protein tyrosine phosphatase , insulin , biology , insulin resistance , microbiology and biotechnology , organic chemistry

The insulin‐enhancing activities of some Cr III complexes, such as [Cr 3 O(OCOEt) 6 (OH 2 ) 3 ] + ( 1 ), previously attributed to specific interactions of Cr III ions with cellular insulin receptors, are more likely to be caused by the formation of [CrO 4 ] 2− ( 2 ). Oxidation of 1 to 2 by biologically relevant oxidants, including enzymes (see scheme), and inhibition of an isolated protein tyrosine phosphatase by a Cr VI complex are reported.

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