Premium
Cationic Planar Chiral Palladium P,S Complexes as Highly Efficient Catalysts in the Enantioselective Ring Opening of Oxa‐ and Azabicyclic Alkenes
Author(s) -
Cabrera Silvia,
Gómez Arrayás Ramón,
Carretero Juan C.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200460087
Subject(s) - cationic polymerization , enantioselective synthesis , catalysis , palladium , chemistry , ring (chemistry) , reagent , trifluoromethyl , zinc , stereochemistry , medicinal chemistry , organic chemistry , alkyl
Open plan : Cationic methylpalladium( II ) complexes of planar chiral Fesulphos ligands (Fesulphos=1‐phosphanyl‐2‐sulfenylferrocene) show excellent performance in the alkylative ring opening of oxa‐ and azabicyclic alkenes with dialkyl zinc reagents (see scheme, Cy=cyclohexyl, Ar F =3,5‐bis(trifluoromethyl)phenyl). Catalyst loadings as low as 0.5 mol % are normally sufficient to achieve high enantioselectivities (94–>99 % ee ).