Cationic Planar Chiral Palladium P,S Complexes as Highly Efficient Catalysts in the Enantioselective Ring Opening of Oxa‐ and Azabicyclic Alkenes | Zendy

Cabrera Silvia | Zendy; Gómez Arrayás Ramón | Zendy; Carretero Juan C. | Zendy

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Cationic Planar Chiral Palladium P,S Complexes as Highly Efficient Catalysts in the Enantioselective Ring Opening of Oxa‐ and Azabicyclic Alkenes

Author(s) -

Cabrera Silvia,

Gómez Arrayás Ramón,

Carretero Juan C.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200460087

Subject(s) - cationic polymerization , enantioselective synthesis , catalysis , palladium , chemistry , ring (chemistry) , reagent , trifluoromethyl , zinc , stereochemistry , medicinal chemistry , organic chemistry , alkyl

Open plan : Cationic methylpalladium( II ) complexes of planar chiral Fesulphos ligands (Fesulphos=1‐phosphanyl‐2‐sulfenylferrocene) show excellent performance in the alkylative ring opening of oxa‐ and azabicyclic alkenes with dialkyl zinc reagents (see scheme, Cy=cyclohexyl, Ar F =3,5‐bis(trifluoromethyl)phenyl). Catalyst loadings as low as 0.5 mol % are normally sufficient to achieve high enantioselectivities (94–>99 % ee ).

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