An SECM Detection Scheme with Improved Sensitivity and Lateral Resolution: Detection of Galactosidase Activity with Signal Amplification by Glucose Dehydrogenase | Zendy

Zhao Chuan | Zendy; Wittstock Gunther | Zendy

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An SECM Detection Scheme with Improved Sensitivity and Lateral Resolution: Detection of Galactosidase Activity with Signal Amplification by Glucose Dehydrogenase

Author(s) -

Zhao Chuan,

Wittstock Gunther

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200454261

Subject(s) - scanning electrochemical microscopy , ultramicroelectrode , chemistry , biosensor , resolution (logic) , signal (programming language) , biophysics , nanotechnology , electrochemistry , analytical chemistry (journal) , materials science , electrode , biochemistry , chromatography , cyclic voltammetry , programming language , biology , artificial intelligence , computer science

An enzymatic amplification cycle is used in a novel detection scheme for scanning electrochemical microscopy (SECM). An immobilized enzyme system comprising galactosidase and PQQ‐dependent glucose dehydrogenase was imaged by SECM with high sensitivity and high lateral resolution. PQQ=pyrroloquinolinequinone.

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