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A Novel Tin‐Free Procedure for Alkyl Radical Reactions
Author(s) -
Benati Luisa,
Leardini Rino,
Minozzi Matteo,
Nanni Daniele,
Scialpi Rosanna,
Spagnolo Piero,
Strazzari Samantha,
Zanardi Giuseppe
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200454245
Subject(s) - radical , tin , alkyl , chemistry , intermolecular force , scheme (mathematics) , combinatorial chemistry , organic chemistry , molecule , mathematics , mathematical analysis
Desulfuration as a source of alkyl radicals : The addition of alkylsulfanyl radicals to isocyanides gives the corresponding alkyl radicals. This methodology can replace the usual tin‐mediated radical procedures and allows for the generation of tertiary, secondary, and even nonstabilized primary radicals that can be used efficiently in reductive defunctionalizations and intermolecular additions to electron‐rich olefins (see scheme).