Unusual Biosynthesis of Leupyrrins in the Myxobacterium  Sorangium cellulosum | Zendy

Bode Helge Björn | Zendy; Wenzel Silke C. | Zendy; Irschik Herbert | Zendy; Höfle Gerhard | Zendy; Müller Rolf | Zendy

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Unusual Biosynthesis of Leupyrrins in the Myxobacterium Sorangium cellulosum

Author(s) -

Bode Helge Björn,

Wenzel Silke C.,

Irschik Herbert,

Höfle Gerhard,

Müller Rolf

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200454240

Subject(s) - myxobacteria , biosynthesis , polyketide , nonribosomal peptide , stereochemistry , chemistry , computational biology , biochemistry , biology , gene , genetics , bacteria

Classical feeding experiments indicate involvement of nonribosomal peptide, polyketide, and isoprenoid biosynthesis in the formation of the myxobacterial antibiotic leupyrrin ( 1 ). The resulting structural elements are modified further (e.g. by a semipinacol‐like rearrangement and oxidative formation of a methylene bridge) to yield the unique leupyrrin framework.

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