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Unusual Biosynthesis of Leupyrrins in the Myxobacterium Sorangium cellulosum
Author(s) -
Bode Helge Björn,
Wenzel Silke C.,
Irschik Herbert,
Höfle Gerhard,
Müller Rolf
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200454240
Subject(s) - myxobacteria , biosynthesis , polyketide , nonribosomal peptide , stereochemistry , chemistry , computational biology , biochemistry , biology , gene , genetics , bacteria
Classical feeding experiments indicate involvement of nonribosomal peptide, polyketide, and isoprenoid biosynthesis in the formation of the myxobacterial antibiotic leupyrrin ( 1 ). The resulting structural elements are modified further (e.g. by a semipinacol‐like rearrangement and oxidative formation of a methylene bridge) to yield the unique leupyrrin framework.