Label‐Free Electrochemical Recognition of DNA Hybridization by Means of Modulation of the Feedback Current in SECM | Zendy

Turcu Florin | Zendy; Schulte Albert | Zendy; Hartwich Gerhard | Zendy; Schuhmann Wolfgang | Zendy

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Label‐Free Electrochemical Recognition of DNA Hybridization by Means of Modulation of the Feedback Current in SECM

Author(s) -

Turcu Florin,

Schulte Albert,

Hartwich Gerhard,

Schuhmann Wolfgang

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200454228

Subject(s) - scanning electrochemical microscopy , oligonucleotide , electrochemistry , chemistry , modulation (music) , amperometry , dna , dna–dna hybridization , biophysics , electrode , nanotechnology , materials science , biochemistry , biology , physics , acoustics

Stranded on the surface : The modulation of the amperometric feedback current in scanning electrochemical microscopy (SECM) through coulomb interactions between the phosphate groups of immobilized oligonucleotides and a freely diffusing, negatively charged redox mediator is used for imaging DNA spots (see picture) and establishing a simple and efficient label‐free electrochemical detection of complementary hybridization on DNA microarrays.

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