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Highly Selective Oligonucleotide‐Based Sensor for Mercury( II ) in Aqueous Solutions
Author(s) -
Ono Akira,
Togashi Humika
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200454172
Subject(s) - mercury (programming language) , oligonucleotide , aqueous solution , chemistry , combinatorial chemistry , computer science , biochemistry , dna , organic chemistry , programming language
Mercury gauge: An oligodeoxyribonucleotide(ODN)‐based sensor, which carries energy‐donor and ‐acceptor moieties (fluorescein, F, and dabcyl, D, respectively), selectively detects Hg II ions in aqueous solution. Upon binding Hg II ions, the ODN takes on a hairpin structure (see picture); this results in a decrease in the fluorescence emission through enhanced FRET (fluorescence resonance energy transfer) from F to D.