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Cobalt( I )‐Catalyzed Asymmetric [2+2+2] Cycloaddition of Alkynes and Nitriles: Synthesis of Enantiomerically Enriched Atropoisomers of 2‐Arylpyridines
Author(s) -
Gutnov Andrey,
Heller Barbara,
Fischer Christine,
Drexler HansJoachim,
Spannenberg Anke,
Sundermann Bernd,
Sundermann Corinna
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200454164
Subject(s) - cycloaddition , catalysis , cobalt , chemistry , medicinal chemistry , nitrile , organic chemistry , combinatorial chemistry
A new flavor of chiral induction in the [2+2+2] cycloaddition yielding pyridines: Atropoisomers were prepared in the reaction of alkynes and nitriles in the presence of 1 mol % chiral Co I catalysts such as 1 with high yields and up to 93 % ee.
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