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Cycloisomerization Promoted by the Combination of a Ruthenium–Carbene Catalyst and Trimethylsilyl Vinyl Ether, and its Application in The Synthesis of Heterocyclic Compounds: 3‐Methylene‐2,3‐dihydroindoles and 3‐Methylene‐2,3‐dihydrobenzofurans
Author(s) -
Terada Yukiyoshi,
Arisawa Mitsuhiro,
Nishida Atsushi
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200454157
Subject(s) - cycloisomerization , ruthenium , carbene , methylene , trimethylsilyl , chemistry , catalysis , ether , organic chemistry , medicinal chemistry , vinyl ether , copolymer , polymer
Substituted N and O heterocycles have been synthesized by the cycloisomerization of dienes using a ruthenium‐carbene catalyst. The products obtained with and without trimethylsilyl vinyl ether differ (see scheme, Cy=cyclohexyl, Mes=2,4,6‐trimethylphenyl, Ts= p ‐toluenesulfonyl).