Identifying Specific Conformations by Using a Carbohydrate Scaffold: Discovery of Subtype‐Selective LPA‐Receptor Agonists and an Antagonist | Zendy

Tamaruya Yoko | Zendy; Suzuki Masato | Zendy; Kamura Goshu | Zendy; Kanai Motomu | Zendy; Hama Kotaro | Zendy; Shimizu Kumiko | Zendy; Aoki Junken | Zendy; Arai Hiroyuki | Zendy; Shibasaki Masakatsu | Zendy

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Identifying Specific Conformations by Using a Carbohydrate Scaffold: Discovery of Subtype‐Selective LPA‐Receptor Agonists and an Antagonist

Author(s) -

Tamaruya Yoko,

Suzuki Masato,

Kamura Goshu,

Kanai Motomu,

Hama Kotaro,

Shimizu Kumiko,

Aoki Junken,

Arai Hiroyuki,

Shibasaki Masakatsu

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200454065

Subject(s) - lysophosphatidic acid , antagonist , chemistry , carbohydrate , acceptor , receptor , hydrogen bond , stereochemistry , small molecule , molecule , biochemistry , organic chemistry , physics , condensed matter physics

Stable and potent subtype‐selective lysophosphatidic acid (LPA) analogues (agonists and an antagonist) were developed by using carbohydrates as a core structure (see scheme). An array of molecules with the recognition motifs of LPA (a phosphate anion, an oleoyl group, and a hydrogen‐bond acceptor) attached to carbohydrate isomers in different three‐dimensional arrangements were tested for LPA‐receptor activation or inhibition. R=alkyl.

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