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Switch Peptides In Statu Nascendi: Induction of Conformational Transitions Relevant to Degenerative Diseases
Author(s) -
Mutter Manfred,
Chandravarkar Arunan,
Boyat Christine,
Lopez John,
Dos Santos Sonia,
Mandal Bhubaneswar,
Mimna Richard,
Murat Karine,
Patiny Luc,
Saucède Lydiane,
Tuchscherer Gabriele
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200454045
Subject(s) - function (biology) , key (lock) , conformational change , neuroscience , transition (genetics) , chemistry , computer science , biology , biochemistry , microbiology and biotechnology , computer security , gene
A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.