Switch Peptides In Statu Nascendi: Induction of Conformational Transitions Relevant to Degenerative Diseases | Zendy

Mutter Manfred | Zendy; Chandravarkar Arunan | Zendy; Boyat Christine | Zendy; Lopez John | Zendy; Dos Santos Sonia | Zendy; Mandal Bhubaneswar | Zendy; Mimna Richard | Zendy; Murat Karine | Zendy; Patiny Luc | Zendy; Saucède Lydiane | Zendy; Tuchscherer Gabriele | Zendy

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Switch Peptides In Statu Nascendi: Induction of Conformational Transitions Relevant to Degenerative Diseases

Author(s) -

Mutter Manfred,

Chandravarkar Arunan,

Boyat Christine,

Lopez John,

Dos Santos Sonia,

Mandal Bhubaneswar,

Mimna Richard,

Murat Karine,

Patiny Luc,

Saucède Lydiane,

Tuchscherer Gabriele

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200454045

Subject(s) - function (biology) , key (lock) , conformational change , neuroscience , transition (genetics) , chemistry , computer science , biology , biochemistry , microbiology and biotechnology , computer security , gene

A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.

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