Alternative Translations of a Single RNA Message: An Identity Switch of (2 S ,3 R )‐4,4,4‐Trifluorovaline between Valine and Isoleucine Codons | Zendy

Wang Pin | Zendy; Fichera Alfio | Zendy; Kumar Krishna | Zendy; Tirrell David A. | Zendy

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Alternative Translations of a Single RNA Message: An Identity Switch of (2 S ,3 R )‐4,4,4‐Trifluorovaline between Valine and Isoleucine Codons

Author(s) -

Wang Pin,

Fichera Alfio,

Kumar Krishna,

Tirrell David A.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200454036

Subject(s) - aminoacylation , valine , isoleucine , transfer rna , translation (biology) , rna , biology , genetics , amino acid , computational biology , leucine , messenger rna , gene

Changed in translation : Bacterial expression hosts can be engineered so that a single RNA message can be read in different ways depending on the relative rates of competing aminoacylation reactions. The (2 S ,3 R )‐4,4,4‐trifluorovaline can be assigned either to isoleucine or to valine codons according to whether the bacterial host overexpresses the isoleucyl‐ or the valyl‐tRNA synthetase (IleRS and ValRS, respectively; see scheme).

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