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Two Metal Ions Coordinated to a Purine Residue Tolerate Each Other Well
Author(s) -
Knobloch Bernd,
Sigel Roland K. O.,
Lippert Bernhard,
Sigel Helmut
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200453987
Subject(s) - guanine , chemistry , nucleobase , metal ions in aqueous solution , metal , ion , diethylenetriamine , aqueous solution , purine , residue (chemistry) , catalysis , inorganic chemistry , stereochemistry , combinatorial chemistry , dna , enzyme , organic chemistry , biochemistry , nucleotide , gene
The catalytic sites of ribozymes generally contain two or more metal ions. Guanine is the nucleobase most often involved in binding to metal ions. The repulsion between two M 2+ ions simultaneously coordinated to guanine in aqueous solution was investigated by using complex 1 (see picture; dien=diethylenetriamine, R=C 2 H 5 ) as a model, for which the stability constants for the binding of Mg 2+ and Cu 2+ were determined.