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Efficient Asymmetric Hydrogenation of Pyridines
Author(s) -
Glorius Frank,
Spielkamp Nick,
Holle Sigrid,
Goddard Richard,
Lehmann Christian W.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200453942
Subject(s) - stereocenter , cleavage (geology) , chirality (physics) , combinatorial chemistry , chemistry , asymmetric hydrogenation , transfer hydrogenation , stereochemistry , enantioselective synthesis , organic chemistry , catalysis , materials science , physics , chiral symmetry , quantum mechanics , quark , fracture (geology) , ruthenium , nambu–jona lasinio model , composite material
Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone‐substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an additional cleavage step unnecessary.