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A Fluorescent Pyrophosphate Sensor with High Selectivity over ATP in Water
Author(s) -
Lee Dong Hoon,
Kim Soon Young,
Hong JongIn
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200453914
Subject(s) - pyrophosphate , fluorescence , chemistry , adenosine triphosphate , selectivity , amine gas treating , adenosine diphosphate , combinatorial chemistry , biochemistry , enzyme , organic chemistry , biology , catalysis , physics , quantum mechanics , platelet , platelet aggregation , immunology
High affinity and selective detection for PPi is exhibited by a new fluorescent sensor based on a naphthalene–dpa system (see picture). The binuclear zinc complex is remarkably selective toward PPi over other anions. For example, PPi can be detected at micromolar concentrations in the presence of a large excess of ATP. PPi=pyrophosphate, ATP=adenosine triphosphate, dpa=bis(2‐pyridylmethyl)amine.