Semisynthesis of a Functional K +  Channel | Zendy

Valiyaveetil Francis I. | Zendy; Sekedat Matthew | Zendy; Muir Tom W. | Zendy; MacKin Roderick | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Semisynthesis of a Functional K + Channel

Author(s) -

Valiyaveetil Francis I.,

Sekedat Matthew,

Muir Tom W.,

MacKin Roderick

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200453849

Subject(s) - kcsa potassium channel , semisynthesis , channel (broadcasting) , chemistry , ion channel , ion , computer science , stereochemistry , telecommunications , biochemistry , organic chemistry , receptor

Selective ion‐conduction properties in lipid membranes have been found for a semisynthetic KcsA K + channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K + channel with chemical modification of the main‐chain atoms of the selectivity filter. The picture shows the single‐channel responses of the semisynthetic K + channel and its structure.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research