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Semisynthesis of a Functional K + Channel
Author(s) -
Valiyaveetil Francis I.,
Sekedat Matthew,
Muir Tom W.,
MacKin Roderick
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200453849
Subject(s) - kcsa potassium channel , semisynthesis , channel (broadcasting) , chemistry , ion channel , ion , computer science , stereochemistry , telecommunications , biochemistry , organic chemistry , receptor
Selective ion‐conduction properties in lipid membranes have been found for a semisynthetic KcsA K + channel containing a mutation (A98G) that allows the channel to open. Thus, it is now possible to study ion conduction in a K + channel with chemical modification of the main‐chain atoms of the selectivity filter. The picture shows the single‐channel responses of the semisynthetic K + channel and its structure.