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A 4‐ exo ‐dig Cyclocarbopalladation/8π Electrocyclization Cascade: Expeditious Access to the Tricyclic Core Structures of the Ophiobolins and Aleurodiscal
Author(s) -
Salem Bahaâ,
Suffert Jean
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200453773
Subject(s) - stille reaction , dig , cascade , tricyclic , construct (python library) , ring (chemistry) , sequence (biology) , core (optical fiber) , chemistry , stereochemistry , computer science , organic chemistry , programming language , telecommunications , world wide web , catalysis , biochemistry , chromatography
New perspectives for an unpopular reaction? An 8π electrocyclization has been used to construct the eight‐membered ring of 5,8,5‐ and 6,4,8,5‐polycyclic systems in a one‐pot 4‐ exo ‐dig cyclocarbopalladation/Stille coupling/electrocyclization sequence (see scheme). The polycycles obtained have the framework of biologically important compounds such as the ophiobolins. R=Et, Me; n =0, 1.