A 4‐ exo ‐dig Cyclocarbopalladation/8π Electrocyclization Cascade: Expeditious Access to the Tricyclic Core Structures of the Ophiobolins and Aleurodiscal | Zendy

Salem Bahaâ | Zendy; Suffert Jean | Zendy

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A 4‐ exo ‐dig Cyclocarbopalladation/8π Electrocyclization Cascade: Expeditious Access to the Tricyclic Core Structures of the Ophiobolins and Aleurodiscal

Author(s) -

Salem Bahaâ,

Suffert Jean

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200453773

Subject(s) - stille reaction , dig , cascade , tricyclic , construct (python library) , ring (chemistry) , sequence (biology) , core (optical fiber) , chemistry , stereochemistry , computer science , organic chemistry , programming language , telecommunications , world wide web , catalysis , biochemistry , chromatography

New perspectives for an unpopular reaction? An 8π electrocyclization has been used to construct the eight‐membered ring of 5,8,5‐ and 6,4,8,5‐polycyclic systems in a one‐pot 4‐ exo ‐dig cyclocarbopalladation/Stille coupling/electrocyclization sequence (see scheme). The polycycles obtained have the framework of biologically important compounds such as the ophiobolins. R=Et, Me; n =0, 1.

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