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An Efficient Synthesis of Diaryl Ketones by Iron‐Catalyzed Arylation of Aroyl Cyanides
Author(s) -
Duplais Christophe,
Bures Filip,
Sapountzis Ioannis,
Korn Tobias J.,
Cahiez Gérard,
Knochel Paul
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200453696
Subject(s) - reagent , aryl , catalysis , chemistry , magnesium , combinatorial chemistry , organic chemistry , alkyl
An alternative to acyl chlorides : Iron( III )‐catalyzed arylation of aroyl and heteroaroyl cyanides with aryl magnesium reagents (see example in scheme) provides an easy and mild approach to polyfunctionalized diaryl ketones in yields up to 98 %.