Total Synthesis and Structural Assignment of Spongidepsin through a Stereodivergent Ring‐Closing‐Metathesis Strategy | Zendy

Chen Jiehao | Zendy; Forsyth Craig J. | Zendy

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Total Synthesis and Structural Assignment of Spongidepsin through a Stereodivergent Ring‐Closing‐Metathesis Strategy

Author(s) -

Chen Jiehao,

Forsyth Craig J.

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200453663

Subject(s) - ring closing metathesis , diastereomer , closing (real estate) , metathesis , stereochemistry , ring (chemistry) , total synthesis , chemistry , key (lock) , natural product , salt metathesis reaction , computer science , organic chemistry , political science , computer security , law , polymerization , polymer

Eight diastereomeric probes ( 1 ) were generated to synthesize the novel, antiproliferative marine natural product spongidepsin ( 2 ) and to determine its absolute stereochemistry. A key step was the formation of the macrocycle by ring‐closing metathesis.

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