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Dithiocarbamate Group Transfer Cyclization Reactions of Carbamoyl Radicals under “Tin‐Free” Conditions
Author(s) -
Grainger Richard S.,
Innocenti Paolo
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200453600
Subject(s) - radical , chemistry , dithiocarbamate , tin , group (periodic table) , free radical reaction , nitrogen , organic chemistry , combinatorial chemistry
Oxygen or nitrogen? Radical chemists overwhelmingly choose to work with xanthates rather than dithiocarbamates, yet the latter offer a distinct advantage in the case of a new method for generating carbamoyl radicals. Functionalized lactams of various ring sizes can be prepared in an operationally simple procedure involving irradiation or heating in the presence of a radical initiator (see scheme).