Cover Picture: DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano‐Ellagitannins in Red Wine (Angew. Chem. Int. Ed. 48/2003) | Zendy

Quideau Stéphane | Zendy; Jourdes Michael | Zendy; Saucier Cédric | Zendy; Glories Yves | Zendy; Pardon Patrick | Zendy; Baudry Christian | Zendy

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Cover Picture: DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano‐Ellagitannins in Red Wine (Angew. Chem. Int. Ed. 48/2003)

Author(s) -

Quideau Stéphane,

Jourdes Michael,

Saucier Cédric,

Glories Yves,

Pardon Patrick,

Baudry Christian

Publication year - 2003

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200390630

Subject(s) - ellagitannin , topoisomerase , wine , int , etoposide , chemistry , dna , biochemistry , biology , polyphenol , genetics , food science , antioxidant , computer science , operating system , chemotherapy

Human DNA topoisomerase II is inhibited in vitro by acutissimin A, a flavano‐ellagitannin, with an activity much higher than that of the clinically used antitumor drug etoposide. Acutissimin A is formed by a non‐enzymatic, yet diastereoselective, condensation reaction occurring during the aging of red wine in oak barrels. S. Quideau et al. report its high‐yielding semi‐synthesis in their Communication on page 6012 ff.

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