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Cover Picture: DNA Topoisomerase Inhibitor Acutissimin A and Other Flavano‐Ellagitannins in Red Wine (Angew. Chem. Int. Ed. 48/2003)
Author(s) -
Quideau Stéphane,
Jourdes Michael,
Saucier Cédric,
Glories Yves,
Pardon Patrick,
Baudry Christian
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390630
Subject(s) - ellagitannin , topoisomerase , wine , int , etoposide , chemistry , dna , biochemistry , biology , polyphenol , genetics , food science , antioxidant , computer science , operating system , chemotherapy
Human DNA topoisomerase II is inhibited in vitro by acutissimin A, a flavano‐ellagitannin, with an activity much higher than that of the clinically used antitumor drug etoposide. Acutissimin A is formed by a non‐enzymatic, yet diastereoselective, condensation reaction occurring during the aging of red wine in oak barrels. S. Quideau et al. report its high‐yielding semi‐synthesis in their Communication on page 6012 ff.