Premium
Cover Picture: “Cascade‐Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core / Self‐Immolative Dendrimers (Angew. Chem. Int. Ed. 37/2003)
Author(s) -
de Groot Franciscus M. H.,
Albrecht Carsten,
Koekkoek Ralph,
Beusker Patrick H.,
Scheeren Hans W.,
Amir Roey J.,
Pessah Neta,
Shamis Marina,
Shabat Doron
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390581
Subject(s) - dendrimer , cascade , chemistry , dissociation (chemistry) , molecule , nanotechnology , combinatorial chemistry , stereochemistry , biophysics , polymer chemistry , materials science , organic chemistry , biology , chromatography
Cascade‐release dendrimers or self‐immolative dendrimers, as shown in the cover picture, spontaneously release all the end‐group molecules following a single activation event. This triggering event induces a cascade of self‐eliminations which leads to complete dissociation of the dendrimer into its separate building blocks. As the research groups of both F. M. H. de Groot (on page 4490 ff) and D. Shabat (on page 4494 ff) describe, such functionally novel dendrimers open up new modes of application of dendrimers, for example, for drug delivery.