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Palladium‐Catalyzed Carbonylation of 2‐(Propargyl)allyl Phosphates Leading to Highly Unsaturated γ‐Lactones
Author(s) -
Kamitani Akihito,
Chatani Naoto,
Murai Shinji
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390359
Subject(s) - propargyl , carbonylation , palladium , catalysis , chemistry , carbon monoxide , organic chemistry , medicinal chemistry
Highly unsaturated γ‐lactones are formed in good to high yields from 2‐(propargyl)allyl phosphates and carbon monoxide in the presence of a palladium catalyst (see scheme). The reaction proceeds efficiently under mild reaction conditions (at 80 °C under an ambient pressure of CO).