Premium
Cu‐Catalyzed Enantioselective Conjugate Additions of Alkyl Zinc Reagents to Unsaturated N ‐Acyloxazolidinones Promoted by a Chiral Triamide Phosphane
Author(s) -
Hird Alexander W.,
Hoveyda Amir H.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200390328
Subject(s) - enantioselective synthesis , conjugate , reagent , chemistry , catalysis , alkyl , zinc , organic chemistry , combinatorial chemistry , mathematical analysis , mathematics
A chiral triamide phosphane promotes highly efficient and enantioselective Cu‐catalyzed conjugate additions of alkyl zinc compounds to unsaturated oxazolidinones (see scheme). The resulting β‐alkyl chiral oxazolidinones are readily converted into synthetically useful carbonyl compounds not accessible by alternative catalytic methods.